what program accesses a file?

[Anthony Tekatch]

Is there a utility that can report on what is accessing a file like
/dev/ttyS0 ?

Recently that serial port has become unusable because something is
transmitting as seen by:
  cat /proc/tty/driver 

Also carefully watching file info using "mc" the Modify time is being
changed but the Access time is remaining the same.

I cannot figure out what process is using that port.

I have a Debian system that was recently fiddled with. Starting with a
Knoppix boot CD proves that the physical port is good.

TIA!

-- 
Anthony
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